منابع مشابه
Neutrophil elastase in bronchiectasis
The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systema...
متن کاملMatrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Neutrophil elastase is the most significant predictor of bronchiectasis in early-life cystic fibrosis; however, the causal link between neutrophil elastase and airway damage is not well understood. Matrix metalloproteinases (MMPs) play a crucial role in extracellular matrix modelling and are activated by neutrophil elastase. The aim of this study was to assess if MMP activation positively corre...
متن کاملEffects of Neutrophil Elastase
A bstract. The effects of neutrophil elastase on endothelial prostacyclin (PGI2) production, nucleotide release, and responsiveness to vasoactive agents were compared with the effects of cathepsin G (the other major neutral protease of neutrophils), pancreatic elastase, trypsin, chymotrypsin, and thrombin. PGI2 production by pig aortic endothelial cells cultured on microcarrier beads and perfus...
متن کاملCrystallization of human neutrophil elastase.
Human neutrophil elastase was inactivated by methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Ala-chloromethane. The modified enzyme was crystallized from 40 mM ammonium phosphate, pH 7.0 in the hexagonal space group P6(3) with unit cell parameters a = 74.53 A, b = 74.53 A, c = 70.88 A, alpha = beta = 90 degrees, gamma = 120 degrees. These crystals were resistant to radiation damage and diffracted beyond 1....
متن کاملNeutrophil elastase and trastuzumab responsiveness.
Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com 4D5. HER2 gene encodes a 185-kDa transmembrane glycoprotein receptor (p185HER2), which is amplified in 25–30% of human breast cancers. When amplified, the gene produces high levels of HER2 surface receptor expression. Patients with breast cancer whose tumors demonstrate HER2 gene amplific...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2017
ISSN: 1465-993X
DOI: 10.1186/s12931-017-0691-x